According to Precidential Decree 32/2004 (A’ 28/6-2-2004) the Secretaries of the Ministerial Council were renamed to “Secretaries General of the Government”
| Full name | from | to | |
|---|---|---|---|
| 1. | Aigialeidis Georgios | – | 25-01-1945 |
| 2. | Chrysomallos Athanasios | 24-01-1945 | 12-04-1946 |
| 3. | Plagiannis Dimitrios | 15-04-1946 | 12-04-1950 |
| 4. | Spyridakis Stavros | 12-04-1950 11-11-1963 | 19-11-1952 07-04-1967 |
| 5. | Bakatsoulas Menelaos | 19-11-1952 | 27-04-1955 |
| 6. | Trivyzas Georgios | 02-08-1955 | 21-05-1958 |
| 7. | Papavlachopoulos Ioannis | 21-05-1958 | 11-11-1963 |
| 8. | Petropoulos Vasileios (temporary Secretary) | 07-04-1967 | 31-12-1968 |
| 9. | Baltas Stavros | 17-01-1969 | – |
| 10. | Mantzouranis Ioannis | 14-01-1982 | 18-01-1984 |
| 11. | Zoras Konstantinos | 19-01-1984 | 26-05-1988 |
| 12. | Lytras Sotirios | 26-05-1988 13-10-1993 | 01-07-1989 06-02-1996 |
| 13. | Voloudakis Evangelos | 02-07-1989 | 13-10-1993 |
| 14. | Mantelis Anastasios | 06-02-1996 | 23-08-1996 |
| 15. | Papadimitriou Georgios | 24-08-1996 | 24-09-1996 |
| 16. | Kosmidis Sokratis | 24-09-1996 | 20-02-2004 |
| 17. | Papadimitriou Georgios | 20-02-2004 | 10-03-2004 |
| 18. | Karras Argyrios | 11-03-2004 | 07-10-2009 |
| 19. | Lytras Sotirios | 07-10-2009 | 20-06-2012 |
| 20. | Baltakos Panagiotis | 20-06-2012 | 04-04-2014 |
| 21. | Kaymenakis Fotios | 04-04-2014 | 27-01-2015 |
| 22. | Sagias Spyridon | 27-01-2015 | 28-08-2015 |
| 23. | Kalogirou Michail | 28-08-2015 | 29-08-2018 |
| 24. | Kaidatzis Akritas | 29-08-2018 | 09-07-2019 |
| 25. | Stylianos – Ioannis Koutnatzis | 09-07-2019 | 09-4-2024 |
| 26. | Christina Tsakona | 09-04-2024 | Σήμερα |